Björkner B, Bruze M, Dahlquist I, Fregert S, Gruvberger B, Persson K
Contact Dermatitis. 1986 Feb;14(2):85-90. doi: 10.1111/j.1600-0536.1986.tb01166.x.
Of 976 patients routinely patch tested with Kathon CG (Rohm & Haas), 300 ppm, 43 (4.4%) gave a positive reaction. Of 170 patients routinely tested with Kathon CG 250 ppm, 10 (5.9%) gave a positive reaction. Out of 34 patients tested with serial dilutions of Kathon CG, 17 (50%) reacted to 100 ppm, 8 to 30 ppm and 2 to 10 ppm. The concentration of 1000 ppm of Kathon CG was irritant in some cases, but 300 ppm was not irritant. Of the 976 patients tested with Kathon CG 300 ppm, 8 (0.8%) showed a "flare-up" reaction, indicating patch test sensitization. Of the 170 tested with Kathon CG 250 ppm, 2 (1.2%) were sensitized. When the patch-test-sensitized patients were retested with serial dilutions, they showed the same pattern as the other patients. 13 sensitized patients were use tested and 7 (54%) gave responses. In the literature, Kathon CG 100 ppm is recommended as the routine patch test concentration. However, 50% of the sensitive persons may then be overlooked. In our clinics, Kathon CG has become the second most common contact sensitizer, but the sensitivity cannot be traced in all patients with clinically relevant allergy without an unacceptable risk of patch test sensitization.
在976名常规接受300 ppm凯松CG（罗门哈斯公司）斑贴试验的患者中，43名（4.4%）出现阳性反应。在170名常规接受250 ppm凯松CG斑贴试验的患者中，10名（5.9%）出现阳性反应。在34名接受凯松CG系列稀释液斑贴试验的患者中，17名（50%）对100 ppm有反应，8名对30 ppm有反应，2名对10 ppm有反应。1000 ppm的凯松CG在某些情况下有刺激性，但300 ppm没有刺激性。在976名接受300 ppm凯松CG斑贴试验的患者中，8名（0.8%）出现“激发”反应，表明斑贴试验致敏。在170名接受250 ppm凯松CG斑贴试验的患者中，2名（1.2%）致敏。当对斑贴试验致敏的患者进行系列稀释液重新测试时，他们表现出与其他患者相同的模式。对13名致敏患者进行了使用测试，7名（54%）有反应。在文献中，推荐100 ppm的凯松CG作为常规斑贴试验浓度。然而，这样可能会忽略50%的敏感人群。在我们的诊所，凯松CG已成为第二常见的接触致敏原，但对于所有有临床相关过敏反应的患者，如果不承担斑贴试验致敏的不可接受风险，就无法检测到其敏感性。
