Renshaw P F, Lafer B, Babb S M, Fava M, Stoll A L, Christensen J D, Moore C M, Yurgelun-Todd D A, Bonello C M, Pillay S S, Rothschild A J, Nierenberg A A, Rosenbaum J F, Cohen B M
Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02178, USA.
Biol Psychiatry. 1997 Apr 15;41(8):837-43. doi: 10.1016/S0006-3223(96)00256-9.
We have investigated proton magnetic resonance spectra of the basal ganglia in 41 medication-free outpatients with major depression, prior to starting an 8-week standardized trial of open-label fluoxetine, and 22 matched comparison subjects. Upon completing the trial, depressed subjects were classified as treatment responders (n = 18) or nonresponders (n = 23), based on changes in the Hamilton Depression Rating Scale. Depressed subjects had a lower area ratio of the choline resonance to the creatine resonance (Cho/Cr) than comparison subjects. This statistically significant difference between the depressed subjects and comparison subjects was more pronounced in the treatment responders than in the nonresponders. There were no differences in the relative volumes of gray matter or white matter in the voxel used for proton spectroscopy in depressed subjects relative to comparison subjects. These results are consistent with an alteration in the metabolism of cytosolic choline compounds in the basal ganglia of depressed subjects and, in particular, those who are responsive to fluoxetine.
我们对41名未服用药物的重度抑郁症门诊患者在开始为期8周的开放标签氟西汀标准化试验之前以及22名匹配的对照受试者的基底神经节质子磁共振波谱进行了研究。试验结束后，根据汉密尔顿抑郁量表的变化，将抑郁患者分为治疗反应者（n = 18）或无反应者（n = 23）。与对照受试者相比，抑郁患者胆碱共振与肌酸共振的面积比（Cho/Cr）较低。抑郁患者与对照受试者之间的这种统计学显著差异在治疗反应者中比在无反应者中更为明显。与对照受试者相比，抑郁患者用于质子波谱分析的体素中灰质或白质的相对体积没有差异。这些结果与抑郁患者，特别是对氟西汀有反应的患者基底神经节中胞质胆碱化合物代谢的改变一致。
