Pillay S S, Yurgelun-Todd D A, Bonello C M, Lafer B, Fava M, Renshaw P F
Brain Imaging Center, McLean Hospital, Belmont, Massachusetts 02178, USA.
Biol Psychiatry. 1997 Jul 15;42(2):79-84. doi: 10.1016/S0006-3223(96)00335-6.
The authors investigated whether there were differences in cerebral and cerebellar gray and white matter volumes in depressed patients compared to controls, and whether this was associated with treatment response to fluoxetine. Brain magnetic resonance images were obtained from 38 unipolar depressed patients and 20 age, gender, and educationally matched comparison subjects. Patients were divided into groups of "responders" and "nonresponders" based on change in 17-item Hamilton Depression Rating Scale (HDRS) after an 8-week standardized trial of fluoxetine, 20 mg/day. There were no group mean differences in cerebral or cerebellar tissue volumes between patients and controls, or responders and nonresponders. For nonresponders to fluoxetine treatment, cerebral and cerebellar gray matter volume, and total cerebellar tissue volume decreased as baseline HDRS increased. The results suggest an association between gray matter volume and severity of illness in nonresponders to fluoxetine treatment.
作者调查了与对照组相比，抑郁症患者的大脑和小脑灰质及白质体积是否存在差异，以及这是否与对氟西汀的治疗反应相关。从38名单相抑郁症患者和20名年龄、性别及教育程度匹配的对照受试者获取脑磁共振图像。在进行为期8周、每天服用20mg氟西汀的标准化试验后，根据17项汉密尔顿抑郁量表（HDRS）的变化，将患者分为“反应者”和“无反应者”两组。患者与对照组之间，以及反应者与无反应者之间，大脑或小脑组织体积无组间平均差异。对于氟西汀治疗无反应者，随着基线HDRS升高，大脑和小脑灰质体积以及小脑总组织体积减小。结果提示，在氟西汀治疗无反应者中，灰质体积与疾病严重程度之间存在关联。
