Adler C H
Parkinson's Disease and Movement Disorders Center, Department of Neurology, Mayo Clinic Scottsdale, AZ 85259, USA.
Clin Neuropharmacol. 1997 Apr;20(2):148-51. doi: 10.1097/00002826-199704000-00006.
Gabapentin is a well tolerated anticonvulsant, structurally related to gamma-aminobutyric acid, with an unknown mechanism of action. Restless legs syndrome (RLS) is a disorder characterized by sensory and motor symptoms in the legs that is best treated with dopaminergic drugs and opiates. In this open-label study, eight patients with RLS were treated with gabapentin. Four of the eight had a beneficial response, three with almost complete resolution of symptoms for up to 6 months. For a disorder that is often difficult to treat, these results are encouraging, and they suggest that a placebo-controlled trial is warranted.
加巴喷丁是一种耐受性良好的抗惊厥药，其结构与γ-氨基丁酸相关，作用机制不明。不安腿综合征（RLS）是一种以腿部感觉和运动症状为特征的疾病，多巴胺能药物和阿片类药物对其治疗效果最佳。在这项开放标签研究中，8例RLS患者接受了加巴喷丁治疗。8例中有4例有有益反应，3例症状几乎完全缓解，持续长达6个月。对于一种通常难以治疗的疾病来说，这些结果令人鼓舞，提示有必要进行一项安慰剂对照试验。
