Happe S, Klösch G, Saletu B, Zeitlhofer J
Department of Clinical Neurology, University of Vienna, Austria.
Neurology. 2001 Nov 13;57(9):1717-9. doi: 10.1212/wnl.57.9.1717.
Nine patients with idiopathic restless legs syndrome (RLS) were treated with 300 mg of gabapentin as an initial dose and an up-titration until relief of symptoms for 4 weeks. Subjective symptoms improved significantly. Polysomnographic data showed a reduction of periodic leg movements during sleep (PLMS) (p = 0.003) and PLMS index (p = 0.001). The authors conclude that gabapentin provides a well-tolerated and effective treatment of idiopathic RLS.
9例特发性不宁腿综合征（RLS）患者接受了加巴喷丁治疗，初始剂量为300mg，然后逐渐增加剂量，直至症状缓解4周。主观症状有显著改善。多导睡眠图数据显示睡眠期周期性腿部运动（PLMS）减少（p = 0.003）以及PLMS指数降低（p = 0.001）。作者得出结论，加巴喷丁对特发性RLS是一种耐受性良好且有效的治疗方法。
