Moll U M, Valea F, Chumas J
Department of Pathology, University Hospital, State University of New York, Stony Brook, USA.
Int J Gynecol Pathol. 1997 Apr;16(2):156-62. doi: 10.1097/00004347-199704000-00012.
Although the clinicopathologic features of primary peritoneal carcinoma (PPC) in women are relatively well defined, the molecular pathogenesis of the disease has not been examined. The object of this study was to assess the biological significance of p53 alterations in PPC. Twenty-nine PPCs studied for p53 protein accumulation with monoclonal antibody DO-7 consisted of 26 serous carcinomas, one clear cell carcinoma, one tumor with endometrioid features, and one malignant mixed müllerian tumor. P53 was overexpressed in 83% of all PPCs and in 81% of the serous PPCs. Among eight immunopositive tumors with at least two distinct anatomic sites sampled, six tumors showed concordance, whereas two tumors showed discordance for p53 immunopositivity. The latter two tumors support the concept of a multifocal origin of PPC. This is the first report to suggest that loss of p53 function plays an important role in the development of PPC and might contribute to the poor prognosis of this disease. Parallels to serous papillary carcinomas of the uterus and ovary are discussed.
尽管女性原发性腹膜癌（PPC）的临床病理特征相对明确，但该疾病的分子发病机制尚未得到研究。本研究的目的是评估p53改变在PPC中的生物学意义。用单克隆抗体DO-7研究p53蛋白积累情况的29例PPC包括26例浆液性癌、1例透明细胞癌、1例具有子宫内膜样特征的肿瘤和1例恶性混合性苗勒管肿瘤。p53在所有PPC的83%以及浆液性PPC的81%中过度表达。在八个至少有两个不同解剖部位取样的免疫阳性肿瘤中，六个肿瘤显示一致，而两个肿瘤在p53免疫阳性方面显示不一致。后两个肿瘤支持PPC多灶起源的概念。这是首次报告表明p53功能丧失在PPC的发展中起重要作用，并可能导致该疾病预后不良。还讨论了与子宫和卵巢浆液性乳头状癌的相似之处。
