Quinn T R, Young R H
Department of Pathology, Harvard Medical School, Boston 02114, USA.
Int J Gynecol Pathol. 1997 Apr;16(2):163-8. doi: 10.1097/00004347-199704000-00013.
Two examples of epidermolytic hyperkeratosis (EH) involving the female genital tract are described. The first case, an isolated epidermolytic acanthoma, involved the vulva of a 75-year-old woman. The second case involved the vaginal wall of a 40-year-old woman who had similar lesions of the oral mucosa. EH is characterized by epidermal acanthosis, compact papillomatous hyperkeratosis, and dissolution of the suprabasilar epithelium, resulting in perinuclear clear zones. Granular keratohyalin clumping, hypergranulosis, and dyskeratosis resulting in intracellular eosinophilic globules ("cells within a cell" appearance) are additional distinctive findings. Because of the rarity of the lesion in the female genital tract, it may be confused with other lesions that more commonly affect this region. Correct recognition of EH may have significant clinical implications.
本文描述了两例累及女性生殖道的表皮松解性角化过度（EH）病例。第一例为孤立性表皮松解性棘皮瘤，发生于一名75岁女性的外阴。第二例累及一名40岁女性的阴道壁，该患者口腔黏膜也有类似病变。EH的特征为表皮棘层增厚、致密乳头瘤样角化过度以及基底上层上皮溶解，导致核周透明区形成。颗粒状透明角质颗粒聚集、颗粒层增厚以及角化不良导致细胞内嗜酸性小球（“细胞内细胞”外观）是另外的特征性表现。由于该病变在女性生殖道中罕见，可能会与更常见累及该区域的其他病变相混淆。正确识别EH可能具有重要的临床意义。
