从西班牙仔猪中分离出的产肠毒素大肠杆菌菌株的定植抗原。
Colonization antigens of enterotoxigenic Escherichia coli strains isolated from piglets in Spain.
作者信息
Garabal J I, Vázquez F, Blanco J, Blanco M, González E A
机构信息
Departamento de Microbioloxía e Parasitoloxía, Facultade de Veterinaria, Universidade de Santiago, Lugo, Spain.
出版信息
Vet Microbiol. 1997 Mar;54(3-4):321-8. doi: 10.1016/s0378-1135(96)01291-6.
Eighty-eight enterotoxigenic E.coli strains isolated from 69 pigs with enteric infections (diarrhoea or oedema disease) were investigated for the presence of F4 (K88), F5 (K99), F6 (987P) and F41 colonization antigens. The commonest colonization antigen was F6 (987P), which was detected in ETEC strains from 31.9% pigs, followed by F5 (K99) 11.6%, F4 (K88) 10.1% and F41 8.7%. Presence of F6 (987P) and F5 (K99) fimbriae was statistically associated (0.025 > p < 0.005) with diarrhoeic piglets younger than 15 days. F4 (K88) colonization antigen was only expressed by ETEC isolated from piglets older than 15 days. 90.5% of ETEC isolated from 90.0% of piglets younger than 15 days expressed F5 (K99), F6 (987P) or F41 antigens, whereas only 31.3% ETEC isolated from piglets older than 15 days were positive for F4 (K88), F5 (K99), F6 (987P) or F41 antigens (p < 0.001). None of the ETEC pigs with oedema disease produced any of the four colonization antigens. ETEC bearing colonization antigens were associated with particular serogroups and toxic phenotypes, whereas 4P- ETEC strains showed diverse phenotypic characteristics.
对从69头患有肠道感染（腹泻或水肿病）的猪中分离出的88株产肠毒素大肠杆菌菌株，检测其是否存在F4（K88）、F5（K99）、F6（987P）和F41定植抗原。最常见的定植抗原是F6（987P），在31.9%的猪的产肠毒素大肠杆菌菌株中检测到，其次是F5（K99）11.6%、F4（K88）10.1%和F41 8.7%。F6（987P）和F5（K99）菌毛的存在与15日龄以下腹泻仔猪有统计学关联（0.025＞p＜0.005）。F4（K88）定植抗原仅由从15日龄以上仔猪分离出的产肠毒素大肠杆菌表达。从90.0%的15日龄以下仔猪分离出的产肠毒素大肠杆菌中，90.5%表达F5（K99）、F6（987P）或F41抗原，而从15日龄以上仔猪分离出的产肠毒素大肠杆菌中，只有31.3%对F4（K88）、F5（K99）、F6（987P）或F41抗原呈阳性（p＜0.001）。患有水肿病的产肠毒素大肠杆菌猪均未产生四种定植抗原中的任何一种。带有定植抗原的产肠毒素大肠杆菌与特定血清群和毒力表型相关，而4P-产肠毒素大肠杆菌菌株表现出多样的表型特征。
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