Todd P
Radiology. 1977 Nov;125(2):493-6. doi: 10.1148/125.2.493.
Biological information suggests that high LET radiations could be used advantageously in radiation therapy. The radiation responses of cells and tissues are described in general terms with respect to the following aspects of high LET radiations considered for therapeutic use: spatial distribution of biological effect, oxygen enhancement of cell lethality in mixed LET radiation beams, dependence of oxygen enhancement of cell lethality upon the microscopic distribution of energy loss, gain factors due to relative biological effectiveness alone, and recovery from sublethal cellular damage. It is concluded that there is no single advantage to the use of high LET radiations in radiation therapy, but that combinations of advantages may exist for different radiations and different tumor-normal tissue combinations. Cases in which inverse gain factors occur are to be avoided.
生物学信息表明，高传能线密度辐射可有效地用于放射治疗。细胞和组织的辐射反应通常从以下几个方面来描述，这些方面是针对用于治疗的高传能线密度辐射而言的：生物效应的空间分布、混合传能线密度辐射束中细胞杀伤的氧增强作用、细胞杀伤的氧增强作用对能量损失微观分布的依赖性、仅因相对生物效应而产生的增益因子以及亚致死性细胞损伤的修复。得出的结论是，在放射治疗中使用高传能线密度辐射不存在单一优势，但不同辐射和不同肿瘤-正常组织组合可能存在优势组合。应避免出现反向增益因子的情况。
