Mansfield C M, Kimler B F, Cheng C C, Abrahams I L, Podrebarac E G, Wittek P J, Reddy E K
J Natl Med Assoc. 1980 Aug;72(8):765-9.
A number of newly synthesized compounds whose chemical structure suggested possible or remotely possible ability to radiosensitize hypoxic mammalian cells were studied in an in-vitro system. Those compounds that were not excluded because of insolubility or extreme cytotoxicity were tested for radiosensitizing ability. The correlation between chemical structure and radiosensitizing ability will be used for the rational design of additional compounds with a high probability of being effective hypoxic cell radiosensitizers. It is hoped that this will contribute to attempts to improve the cure rate of patients with malignant tumors through the use of radiation therapy and hypoxic cell radiosensitizers.
在体外系统中研究了许多新合成的化合物，这些化合物的化学结构表明它们有可能或极有可能使缺氧哺乳动物细胞产生放射增敏作用。那些未因不溶性或极端细胞毒性而被排除的化合物被测试了放射增敏能力。化学结构与放射增敏能力之间的相关性将用于合理设计其他极有可能成为有效缺氧细胞放射增敏剂的化合物。希望这将有助于通过使用放射治疗和缺氧细胞放射增敏剂来提高恶性肿瘤患者治愈率的尝试。
