Sing A, Freudenberg N, Kortsik C, Wertzel H, Klosa B, Hasse J
Department of Pathology, Albert-Ludwigs-Universität, Freiburg, Germany.
Acta Cytol. 1997 Mar-Apr;41(2):399-408. doi: 10.1159/000332531.
To describe the role of sputum and brush cytology in the diagnosis of lung carcinoma and to elucidate the influence of tumor location, histologic tumor type and stage on the sensitivity of both methods.
Retrospective and performed on 415 lung cancer patients. Two hundred of them were investigated only by sputum collection, 119 only by brushing and 96 by both methods.
The overall sensitivity of the sputum technique was 0.403 and that of the brush method 0.500, while a combination of both showed a sensitivity of 0.640. The diagnostic yield depended on tumor location, histologic tumor type and stage. Sputum specimens were most valuable in the detection of early and peripheral carcinomas, whereas brushing was superior in finding more advanced and centrally located malignancies. Regarding tumor type, squamous cell carcinomas were diagnosed to the greatest extent by both methods.
A complementary role of both cytologic techniques can be postulated by our data as well as by a literature review.
描述痰液和刷片细胞学检查在肺癌诊断中的作用，并阐明肿瘤位置、组织学肿瘤类型和分期对这两种方法敏感性的影响。
对415例肺癌患者进行回顾性研究。其中200例仅通过痰液采集进行检查，119例仅通过刷片检查，96例两种方法都采用。
痰液技术的总体敏感性为0.403，刷片法为0.500，而两种方法联合使用时敏感性为0.640。诊断率取决于肿瘤位置、组织学肿瘤类型和分期。痰液标本在早期和周围型癌的检测中最有价值，而刷片在发现更晚期和中央型恶性肿瘤方面更具优势。就肿瘤类型而言，两种方法对鳞状细胞癌的诊断率最高。
根据我们的数据以及文献综述，可以推测这两种细胞学技术具有互补作用。
