Romanovsky A A, Shido O, Sakurada S, Sugimoto N, Nagasaka T
Department of Physiology, University of Kanazawa Medical School, Japan.
Ann N Y Acad Sci. 1997 Mar 15;813:733-7. doi: 10.1111/j.1749-6632.1997.tb51775.x.
In sum, our results indicate that LPS shock-associated hypothermia involves the following major mechanisms: 1) a decrease in the threshold Tb for activation of cold thermogenesis; 2) the resultant widening of the interthreshold zone; and 3) cold-seeking behavior. We speculate that, in severe systemic inflammation, this hypothermia constitutes an adaptive response.
总之，我们的结果表明，脂多糖休克相关的体温过低涉及以下主要机制：1）激活冷产热的阈值体温（Tb）降低；2）由此导致的阈值间区域变宽；3）寻冷行为。我们推测，在严重的全身炎症中，这种体温过低构成一种适应性反应。
