Xiang Z, Ariyoshi K, Wilkins A, Dias F, Whittle H, Breuer J
Department of Virology, London Hospital Medical College, England.
AIDS Res Hum Retroviruses. 1997 Apr 10;13(6):501-5. doi: 10.1089/aid.1997.13.501.
Data from an MRC case-control study in rural Guinea Bissau suggest older HIV-2 carriers (aged 55 to 80 years) appear, over a period of 2 years, to have a mortality similar to that of uninfected controls, whereas in HIV-2 carriers under the age of 55 there is a significantly higher mortality, compared with uninfected controls. Genotyping of viruses from both groups revealed only subtype a to be circulating. Thus, although putative nonpathogenic HIV-2 subtypes have been described in patients from West Africa, these do not appear to be contributing significantly to the nonpathogenic clinical phenotype in this population.
来自几内亚比绍农村地区一项医学研究委员会病例对照研究的数据表明，年龄较大的HIV-2携带者（55至80岁）在两年时间里的死亡率似乎与未感染的对照组相似，而55岁以下的HIV-2携带者的死亡率与未感染的对照组相比则显著更高。对两组病毒进行基因分型后发现，只有A型亚型在传播。因此，尽管在西非患者中已描述了假定的非致病性HIV-2亚型，但这些亚型似乎并未对该人群的非致病性临床表型产生显著影响。
