低剂量丝裂霉素C辅助小梁切除术：一项前瞻性对照研究。
Low-dosage mitomycin C as an adjunct to trabeculectomy. A prospective controlled study.
作者信息
Martini E, Laffi G L, Sprovieri C, Scorolli L
机构信息
Department of Physiopathologic Optics, University of Bologna, Italy.
出版信息
Eur J Ophthalmol. 1997 Jan-Mar;7(1):40-8. doi: 10.1177/112067219700700108.
PURPOSE
To assess the advantages and adverse effects of intraoperative low-dose Mitomycin C in filtering glaucoma surgery.
METHODS
Sixty eyes of 48 patients undergoing surgery for uncontrolled glaucoma were randomized to two groups: one underwent standard trabeculectomy, the other had trabeculectomy with intraoperative application of 0.1 mg/ml mitomycin C. Follow-up was at least one year.
RESULTS
The success rate (IOP < 18 mmHg) was 96.6% in the mitomycin C group and 73.3% in the control group. Mean IOP at one year of successful cases was 11.1 +/- 3.1 mmHg in the mitomycin C group and 16.4 +/- 6.1 mmHg in controls (p < 0.0001). Two patients in the mitomycin C group (6.6%) and six (20%) in the control group needed antiglaucomatous drugs to keep IOP below 18 mmHg.
CONCLUSIONS
Mitomycin C is a useful adjunct to glaucoma surgery. Adverse effects at the dosage used are mainly due to hypotony and are preventable with two-layer suture. Low-dose mitomycin C may be useful in standard primary trabeculectomy.
目的
评估术中低剂量丝裂霉素C在青光眼滤过手术中的优势及不良反应。
方法
48例接受手术治疗的难治性青光眼患者的60只眼被随机分为两组：一组接受标准小梁切除术，另一组在术中应用0.1mg/ml丝裂霉素C进行小梁切除术。随访至少一年。
结果
丝裂霉素C组成功率（眼压<18mmHg）为96.6%，对照组为73.3%。成功病例术后一年时，丝裂霉素C组平均眼压为11.1±3.1mmHg，对照组为16.4±6.1mmHg（p<0.0001）。丝裂霉素C组有2例患者（6.6%），对照组有6例患者（20%）需要使用抗青光眼药物以使眼压维持在18mmHg以下。
结论
丝裂霉素C是青光眼手术的一种有用辅助药物。所用剂量的不良反应主要是由于低眼压，采用双层缝合可预防。低剂量丝裂霉素C可能对标准原发性小梁切除术有用。
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