Lin F M, Pan Y C, Dinh T A, Sabbahi M, Shenaq S
Division of Plastic Surgery, Baylor College of Medicine, Houston, Texas, USA.
J Reconstr Microsurg. 1997 Apr;13(3):177-83. doi: 10.1055/s-2007-1006402.
The purpose of this study was to investigate gait-pattern changes after complete tibial nerve lesion in the cat, and to observe whether nerve repair could reverse some of the changes. In six cats, a 5-cm segment of the tibial nerve was transected. The nerve gap was then repaired with nerve autograft in three animals and was unrepaired in three as controls. The walking patterns of the cats were videotaped, and the hip, knee, ankle, and metatarsophalangeal joint angles were measured at the beginnings of the F, E1, E2, and E3 phases of the step cycle. Two weeks after surgery, abnormal gait patterns were observed, and four gait parameters (E3.Hip, E3.Ankle, E3.M-P, and F.Ankle) were found to be statistically significantly different from normal. Six months after surgery, the nerve-graft group had gait-parameter values approaching normal, while the control group showed no measurable improvement. Correspondingly, electrophysiologic testing revealed considerable nerve regeneration in the nerve-graft group but not in the control group. It was concluded that these gait parameters can be used as valid functional indices to evaluate the degree of tibial nerve recovery in the cat model.
本研究的目的是调查猫的胫神经完全损伤后的步态模式变化，并观察神经修复是否能逆转其中一些变化。在6只猫中，切断5厘米长的胫神经段。然后，3只动物用自体神经移植修复神经缺损，3只作为对照未进行修复。拍摄猫的行走模式，并在步周期的F、E1、E2和E3阶段开始时测量髋、膝、踝和跖趾关节角度。术后两周，观察到异常步态模式，发现四个步态参数（E3.髋、E3.踝、E3.跖趾关节和F.踝）与正常情况有统计学显著差异。术后六个月，神经移植组的步态参数值接近正常，而对照组未显示出可测量的改善。相应地，电生理测试显示神经移植组有相当程度的神经再生，而对照组则没有。得出的结论是，这些步态参数可作为有效的功能指标，用于评估猫模型中胫神经的恢复程度。
