Nomura K
Laboratory of Veterinary Surgery, College of Agriculture, Osaka Prefecture University, Japan.
J Vet Med Sci. 1997 Mar;59(3):185-90. doi: 10.1292/jvms.59.185.
Bitches were examined to see whether canine deciduoma could be induced at some reproductive stages with the different conditions of corpora lutea by inserting a silk suture into the uterine lumen. The bitches stimulated in the early and middle stages of diestrus or in unilateral pregnancy corresponding to these diestrous stages formed deciduoma at a high induction rate, however, no difference in the strength of decidual reaction between the pregnant and diestrous stages was recognized. On the other hand, no reaction could be seen in bitches in late diestrus, the late stage of unilateral pregnancy or the post partum repair phase in which stromal decidual cells similar to those of the rodentia can be seen. In already implanted uteri, however, no deciduoma was formed in the interplacental areas. Even though the corpora lutea were functional, new additional stimulations were not accepted at the interplacental area in which the uterine horn had already been influenced by fertilized ova. From these results, it was suggested that in the dog as well as the rodentia, the endometrium has to be under the influence of functional corpora lutea in order to form deciduoma.
通过向子宫腔内插入丝线，对母犬进行检查，以观察在不同黄体状态的某些生殖阶段是否能诱发犬蜕膜瘤。在发情后期和中期受到刺激的母犬，或处于与这些发情阶段相对应的单侧妊娠状态的母犬，形成蜕膜瘤的诱导率很高，然而，未发现妊娠阶段和发情阶段之间的蜕膜反应强度有差异。另一方面，在发情后期、单侧妊娠后期或产后修复阶段的母犬中未观察到反应，而在这些阶段可以看到与啮齿动物相似的基质蜕膜细胞。然而，在已经着床的子宫中，胎盘间区域未形成蜕膜瘤。即使黄体功能正常，在子宫角已经受到受精卵影响的胎盘间区域，也不会接受新的额外刺激。从这些结果可以看出，与啮齿动物一样，犬的子宫内膜必须在功能性黄体的影响下才能形成蜕膜瘤。
