甲型禽流感病毒在雏鸡中引发类似发育迟缓综合征的疾病。

Avian influenza A virus induced stunting syndrome-like disease in chicks.

作者信息

Silvano F D, Kanata Y, Takeuchi M, Shimada A, Otsuki K, Umemura T

机构信息

Department of Veterinary Pathology, Faculty of Agriculture, Tottori University, Japan.

出版信息

J Vet Med Sci. 1997 Mar;59(3):205-7. doi: 10.1292/jvms.59.205.

DOI:10.1292/jvms.59.205

PMID:9101480

Abstract

Two-day-old specific-pathogen free chicks were inoculated with type A influenza virus (A/whistling swan/Shimane/499/83 (H5N3) through the air sac. Inoculated chicks showed mild to severe diarrhea and lesions of pancreatitis and atrophy of the pancreas, thymus and bursa of Fabricius. One chick died on each of days 4, 6 and 14 postinoculation (PI). Reduced weight gain was conspicuous from day 22 PI. Positive immunoreaction to the virus antigen was detected in the pancreas, kidneys, liver, lungs and air sacs, and cecal lamina propria. Virus recovery persisted longer in the pancreas. Some of these findings conformed to those of stunting syndrome.

摘要

将2日龄的无特定病原体雏鸡通过气囊接种A型流感病毒（A/whistling swan/Shimane/499/83 (H5N3)）。接种后的雏鸡出现轻度至重度腹泻、胰腺炎病变以及胰腺、胸腺和法氏囊萎缩。接种后第4天、第6天和第14天各有1只雏鸡死亡。从接种后第22天起体重增加明显减少。在胰腺、肾脏、肝脏、肺脏、气囊和盲肠固有层检测到对病毒抗原的阳性免疫反应。病毒在胰腺中持续存在的时间更长。其中一些发现与发育迟缓综合征的表现相符。