Martin K, Lethbridge-Cejku M, Muller D C, Elahi D, Andres R, Tobin J D, Hochberg M C
Department of Medicine, University of Maryland School of Medicine, Baltimore, USA.
J Rheumatol. 1997 Apr;24(4):702-7.
To examine the relationship between metabolic correlates of obesity and radiographic knee osteoarthritis (OA).
We included 464 Caucasian men and 275 Caucasian women aged 40 years and above who were participants in the Baltimore Longitudinal Study of Aging. Subjects had bilateral anteroposterior standing knee radiographs read for features of OA using Kellgren-Lawrence scales. Resting blood pressure, fasting lipids, 2 h oral glucose tolerance test, and anthropometric measurements were obtained at the same visit as the knee radiograph. Metabolic correlates of obesity were compared between subjects with Kellgren-Lawrence grade > or = 2 (definite knee OA) and grade 0 (normal radiograph) by sex.
Both men and women with knee OA had higher unadjusted systolic blood pressure than those with normal knee radiographs; unadjusted measures of glucose metabolism and lipids did not vary by presence of knee OA in men or women. After adjustment for age and obesity, systolic blood pressure did not vary by presence of knee OA in men. While women with knee OA did have higher adjusted mean systolic blood pressure than women with normal radiographs (127 +/- 2.4 vs 120 +/- 2.2 mm Hg; p = 0.04), both values were within normal range. Unexpectedly, men with knee OA had lower adjusted mean 2 h glucose levels compared to men without OA (7.5 +/- 0.2 vs 8.4 +/- 0.2 mmol/l; p = 0.01). Other adjusted variables did not differ by presence of knee OA.
These data do not support the hypothesis that metabolic correlates of obesity are independently associated with radiographic knee OA after adjustment for age and obesity.
研究肥胖的代谢相关因素与膝关节X线骨关节炎（OA）之间的关系。
我们纳入了464名40岁及以上的白种男性和275名白种女性，他们均为巴尔的摩纵向衰老研究的参与者。对受试者进行双侧膝关节前后位站立位X线片检查，采用Kellgren-Lawrence量表评估OA特征。在与膝关节X线片检查同期进行的检查中，测量静息血压、空腹血脂、口服葡萄糖耐量试验2小时血糖以及人体测量指标。按性别比较Kellgren-Lawrence分级>或 = 2（确诊膝关节OA）和0级（X线片正常）受试者的肥胖代谢相关因素。
膝关节OA的男性和女性未经调整的收缩压均高于膝关节X线片正常者；男性和女性的葡萄糖代谢及血脂未经调整的测量值不因是否存在膝关节OA而有所不同。在调整年龄和肥胖因素后，男性的收缩压不因是否存在膝关节OA而有所变化。虽然膝关节OA的女性经调整后的平均收缩压确实高于X线片正常的女性（127±2.4 vs 120±2.2 mmHg；p = 0.04），但这两个值均在正常范围内。出乎意料的是，与无OA的男性相比，膝关节OA的男性经调整后的平均2小时血糖水平较低（7.5±0.2 vs 8.4±0.2 mmol/l；p = 0.01）。其他经调整的变量不因是否存在膝关节OA而有所不同。
这些数据不支持以下假设，即在调整年龄和肥胖因素后，肥胖的代谢相关因素与膝关节X线OA独立相关。
