Division of Orthopaedic Surgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
Orthop Surg. 2014 Feb;6(1):23-7. doi: 10.1111/os.12093.
To determine whether the prevalence of severe spinal osteoarthritis (OA) increases with the number of metabolic syndrome (MetS) risk factors.
Data from a single surgeon's high volume, spine surgery practice were reviewed. Severe OA was defined as degenerative spondylolisthesis or cervical or lumbar stenosis causing neurologically based symptoms and early OA as lumbar and cervical spondylosis causing axial pain only. Logistic regression modeling was used to determine the odds (adjusted for age and sex) of having severe spine OA with more numerous MetS risk factors.
Severe spinal OA was identified in 839/1502 patients (55.9%) and early OA in the remaining 663 individuals (44.1%). The overall prevalence of MetS was 30/1502 (2.0%): 26/839 (3.1%) in the severe OA group and 4/663 (0.6%) in the early OA group (P = 0.001). Presence of all four MetS risk factors was associated with almost quadruple the odds of having severe OA as compared with absence of risk factors (OR 3.9 [1.4-11.6], P < 0.01).
The components of MetS are more prevalent in subjects with severe spinal OA than in those with spondylosis causing axial pain. Future study of the association between MetS and the incidence of OA is required.
确定代谢综合征（MetS）危险因素的数量是否与严重脊柱骨关节炎（OA）的患病率增加有关。
回顾了一位外科医生的大容量脊柱手术实践中的数据。严重 OA 定义为退行性脊椎滑脱或颈椎或腰椎狭窄导致神经相关症状，早期 OA 定义为仅引起轴向疼痛的腰椎和颈椎骨关节炎。使用逻辑回归模型确定具有更多 MetS 危险因素的严重脊柱 OA 的可能性（调整年龄和性别）。
在 1502 名患者中发现了 839 名（55.9%）严重脊柱 OA，其余 663 名（44.1%）为早期 OA。MetS 的总体患病率为 30/1502（2.0%）：严重 OA 组中为 26/839（3.1%），早期 OA 组中为 4/663（0.6%）（P = 0.001）。存在所有四个 MetS 危险因素与存在危险因素相比，发生严重 OA 的可能性几乎增加了四倍（OR 3.9 [1.4-11.6]，P <0.01）。
与引起轴向疼痛的脊柱关节炎相比，代谢综合征的成分在严重脊柱 OA 患者中更为普遍。需要进一步研究 MetS 与 OA 发生率之间的关联。
