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髋膝关节骨关节炎的疼痛功能指标。

The algofunctional indices for hip and knee osteoarthritis.

作者信息

Lequesne M G

机构信息

Rheumatology Department, Léopold Bellan Hospital, Paris, France.

出版信息

J Rheumatol. 1997 Apr;24(4):779-81.

PMID:9101517
Abstract

The severity or algofunctional indices for hip and knee osteoarthritis (OA) have been used in Europe for about 10 years. They were validated, then published between 1982 and 1987. They are useful mainly as outcome measures in OA trials, and also for appraising the severity of patient function: a score above 11-12 points after appropriate treatment indicates surgery. Most patients recruited in OA trials have a score of 9-11 (SD 2.3 to 3.8), decreasing about 30 to 40% with the active drug. The effect size reaches 1.3 to 1.8. The indices have 2 advantages: they are structured separately for hip and for knee OA and the same instrument serves as a measure of severity (disability scale) and as an outcome measurement tool in trials.

摘要

髋膝关节骨关节炎(OA)的严重程度或疼痛功能指标在欧洲已使用约10年。这些指标经过验证,于1982年至1987年间发表。它们主要作为OA试验的疗效指标,也用于评估患者功能的严重程度:经过适当治疗后得分高于11 - 12分表明需要手术。在OA试验中招募的大多数患者得分为9 - 11分(标准差为2.3至3.8),使用活性药物后得分下降约30%至40%。效应大小达到1.3至1.8。这些指标有两个优点:它们分别针对髋部和膝部OA进行构建,并且同一工具既用作严重程度的衡量指标(残疾量表),又用作试验中的疗效测量工具。

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