Sugihara K, Moriya Y, Akasu T, Fujita S
Department of Surgery, National Cancer Center Hospital, Tokyo, Japan.
Nihon Geka Gakkai Zasshi. 1997 Mar;98(3):391-5.
Sphincter saving procedure (SSP) was applied when, for tumor which were a localized type and well or moderate differentiated adenocarcinoma, distal clearance margin (AW) more than 2 cm was obtained and when, for tumor which was a infiltrated type or adenocarcinoma with other pathological grades, AW more than 3 cm was obtained. Between 1984 and 1993, 209 patients with rectal carcinomas, the lower border of which was located below the peritoneal reflexion, underwent curative surgery: SSP in 114 and abdominoperineal resection (APR) in 95. The APR group included more advanced cases both in the depth of invasion and in lymph node metastases (p = 0.011, p = 0.059, respectively). During the median follow-up of 68.6 months, recurrent tumors were developed in 17.5% of the SSP and in 30.5% of the APR (p = 0.027). The patients with SSP showed better prognosis than those with APR(p = 0.0007), with the 5 year survival rate of 80.2% and 70.0%, respectively. The difference may be due to higher incidence of hematogenous metastases in the APR (26.3%) than in the SSP (13.2%). There was no difference in local recurrences between them. When function after SSP was compared with that after anterior resection for middle or upper rectal carcinomas, no difference was observed between them, although most patients of the both groups complained of increased frequency of defecation and occasional soiling. The criteria of SSP for low located rectal carcinoma may be adequate with the acceptable oncological outcome, but altered function after SSP should be improved.
对于局限性、高分化或中分化腺癌的肿瘤,当远端切缘(AW)大于2 cm时,以及对于浸润型或其他病理分级的腺癌,当AW大于3 cm时,采用保括约肌手术(SSP)。1984年至1993年期间,209例下缘位于腹膜反折以下的直肠癌患者接受了根治性手术:114例行SSP,95例行腹会阴联合切除术(APR)。APR组在浸润深度和淋巴结转移方面均包括更晚期的病例(分别为p = 0.011,p = 0.059)。在中位随访68.6个月期间,SSP组17.5%出现复发性肿瘤,APR组为30.5%(p = 0.027)。SSP患者的预后优于APR患者(p = 0.0007),5年生存率分别为80.2%和70.0%。这种差异可能是由于APR组血行转移发生率(26.3%)高于SSP组(13.2%)。两组局部复发率无差异。将SSP后的功能与中高位直肠癌前切除术后的功能进行比较时,两组之间未观察到差异,尽管两组大多数患者都抱怨排便频率增加和偶尔失禁。低位直肠癌SSP的标准可能是合适的,肿瘤学结果可以接受,但SSP后改变的功能应得到改善。