Khan S A, Nyce J W
Department of Molecular Pharmacology & Therapeutics, School of Medicine, East Carolina University, Greenville, NC 27858, USA.
Pharmacol Toxicol. 1997 Mar;80(3):118-21. doi: 10.1111/j.1600-0773.1997.tb00383.x.
The adrenal steroid, dehydroepiandrosterone (DHEA) has been identified as a peroxisome proliferator. We examined the effects of the cellular antioxidant ubiquinone and its precursor mevalonic acid on the induction of enzymes associated with DHEA-mediated peroxisome proliferation in male F-344 rats. Upon treatment with DHEA (300 mg/kg orally for 14 days), there was a significant increase in hepatic activities of peroxisomal beta-oxidation (3 fold), 3-ketoacyl-CoA thiolase (4 fold) and catalase (1.8 fold). Co-administration of either mevalonic acid (100 mg/kg intraperitoneally) or ubiquinone (50 mg/kg orally) with DHEA significantly attenuated the DHEA-mediated induction of these enzymes. However, neither ubiquinone nor mevalonic acid alone significantly altered peroxisomal enzyme activities in rat liver. These data suggest that exogenous administration of ubiquinone or mevalonic acid can modulate the induction of the enzymes involved in peroxisome proliferation.
肾上腺类固醇脱氢表雄酮（DHEA）已被确定为一种过氧化物酶体增殖剂。我们研究了细胞抗氧化剂泛醌及其前体甲羟戊酸对雄性F-344大鼠中与DHEA介导的过氧化物酶体增殖相关的酶诱导作用的影响。用DHEA（300 mg/kg口服，持续14天）处理后，过氧化物酶体β-氧化（3倍）、3-酮酰基辅酶A硫解酶（4倍）和过氧化氢酶（1.8倍）的肝脏活性显著增加。甲羟戊酸（100 mg/kg腹腔注射）或泛醌（50 mg/kg口服）与DHEA共同给药可显著减弱DHEA介导的这些酶的诱导作用。然而，单独使用泛醌或甲羟戊酸均未显著改变大鼠肝脏中的过氧化物酶体酶活性。这些数据表明，外源性给予泛醌或甲羟戊酸可调节参与过氧化物酶体增殖的酶的诱导作用。
