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[术中失血对上消化道肿瘤自然杀伤细胞功能的影响]

[Effect of intraoperative blood loss on the function of natural killer cells in tumors of the upper gastrointestinal tract].

作者信息

Bruns C J, Schäfer H, Wolfgarten B, Engert A

机构信息

Klinik und Poliklinik für Chirurgie, Universität zu Köln.

出版信息

Langenbecks Arch Chir Suppl Kongressbd. 1996;113:146-9.

PMID:9101816
Abstract

The activity of natural killer cells was measured perioperatively in 39 patients with esophageal and gastric cancer and was correlated with intraoperative blood loss. The activity of natural killer cells in all patients sank significantly (p < 0.05) on the fourth postoperative day to their original values. In the 24 patients with an intraoperative blood loss of more than 700 ml, the activity of the natural killer cells decreased significantly (p < 0.05) on the fourth postoperative day, in contrast to those 15 patients with an intraoperative blood loss of less than 500 ml; intraoperative blood loss and activity of natural killer cells show a correlation of R2 0.82.

摘要

对39例食管癌和胃癌患者围手术期的自然杀伤细胞活性进行了测定,并将其与术中失血量进行关联分析。所有患者的自然杀伤细胞活性在术后第四天显著下降(p<0.05),降至原始值。在术中失血量超过700ml的24例患者中,自然杀伤细胞活性在术后第四天显著降低(p<0.05),而术中失血量少于500ml的15例患者则不然;术中失血量与自然杀伤细胞活性的相关性R2为0.82。

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