Gebhard F, Rösch M, Strecker W, Kinzl L, Brückner U B
Abteilung für Unfallchirurgie, Hand- und Wiederherstellungschirurgie, Universität Ulm.
Langenbecks Arch Chir Suppl Kongressbd. 1996;113:331-3.
Prostanoids are inflammatory mediators which originate from endothelial cells following local tissue damage. That is why plasma levels of prostanoids are possible markers of inflammatory response and severity of trauma. We were able to demonstrate that the systemic release of prostanoids does not depend on the score values (ISS, PTS) but rather on different trauma patterns (chest trauma, head injury). Influencing vascular permeability and resistance elevated plasma levels of prostanoids may explain the impairment of pulmonary function in traumatized patients. It seems to be useful to re-evaluate the scoring systems with respect to chest trauma and head injury.
前列腺素是炎症介质，在局部组织损伤后由内皮细胞产生。这就是为什么前列腺素的血浆水平可能是炎症反应和创伤严重程度的标志物。我们能够证明，前列腺素的全身释放并不取决于评分值（损伤严重度评分、创伤后评分），而是取决于不同的创伤模式（胸部创伤、头部损伤）。影响血管通透性和阻力，升高的前列腺素血浆水平可能解释创伤患者肺功能的损害。重新评估针对胸部创伤和头部损伤的评分系统似乎是有用的。
