Schultheis K H, Baumann M, Meyer W, Gebhardt C, Mittelmeier H O, Wünsch P
Klinik für Viszeral-, Thorax- und Endokrine Chirurgie, Städtisches Klinikum Nürnberg Nord.
Langenbecks Arch Chir Suppl Kongressbd. 1996;113:775-8.
Between 1 Jan 1984-1 Jan 1990, 199 patients underwent curative (R0) surgery for non-small cell lung cancer. The pathohistological findings showed that a carcinomatous lymphangiosis and haemangiosis (L/H pos.) were present in 26 patients. In six patients, no lymph node metastases were detected. The median (22 mo. vs. 74 mo.) and 5-year survival (25% vs. 41%) were significantly (p < 0.001) higher compared to patients with and without lymphangiosis and haemangiosis carcinomatosa (L/H neg.). There were also significant (p < 0.05) differences in the survival time between pNO L/H neg. and pNO L/H pos. patients (median 74 mo. vs. 15 mo.-5 years 43% vs. 0%).
1984年1月1日至1990年1月1日期间，199例非小细胞肺癌患者接受了根治性（R0）手术。病理组织学检查结果显示，26例患者存在癌性淋巴管炎和血管炎（L/H阳性）。其中6例患者未检测到淋巴结转移。与有或无癌性淋巴管炎和血管炎（L/H阴性）的患者相比，L/H阳性患者的中位生存期（22个月对74个月）和5年生存率（25%对41%）显著更高（p<0.001）。pNO L/H阴性和pNO L/H阳性患者的生存时间也存在显著差异（p<0.05）（中位生存期74个月对15个月，5年生存率43%对0%）。
