Belov B S, Shubin S V, Nasonova V A, Soldatova S I, Tarasova G M, Urumova M M, Ushakova M A, Anan'eva L P
Vestn Ross Akad Med Nauk. 1996(12):12-5.
The efficacy and tolerance of 3 fluoroquinolones (ciprofloxacin, pefloxacin, lomefloxacin) were studied in 157 patients with rheumatic diseases concurrent with infection-induced abnormalities. Infection cure was achieved in 123 (78.6%) patients, as evidenced by clinical, microbiological, and serological studies. The tolerance of fluoroquinolones was regarded as good, satisfactory, and poor in 114 (72.6%), 37 (23.6%), and 6 (3.8%) patients, respectively. All representative drugs of the fluoroquinolones series produced typical adverse reactions. The authors consider it expedient to make further clinical studies to test the optimal treatment regimens and to expand indications for the use of fluoroquinolones in this group of patients.
对157例合并感染性异常的风湿性疾病患者研究了3种氟喹诺酮类药物（环丙沙星、培氟沙星、洛美沙星）的疗效和耐受性。临床、微生物学和血清学研究证明，123例（78.6%）患者感染治愈。氟喹诺酮类药物的耐受性在114例（72.6%）、37例（23.6%）和6例（3.8%）患者中分别被视为良好、满意和差。氟喹诺酮类系列的所有代表性药物均产生典型不良反应。作者认为进一步开展临床研究以测试最佳治疗方案并扩大氟喹诺酮类药物在该组患者中的应用指征是适宜的。
