Frundzhian V G, Romanova N A, Dement'eva E I, Brovko L Iu, Ugarova N N, Novikov K N, Brusovanik V I, Kobialko V O, Meshkov N A
Radiats Biol Radioecol. 1997 Jan-Feb;37(1):13-9.
The bioluminescent method was used in the studies of the influence of ionizing irradiation and/or xenobiotics on the content of ATP in RBC and neutrophils of rats, and in whole blood and neutrophils of 80 examined women of Altai Region exposed to ionizing radiation during a series of nuclear tests in Semipalatinsk in 1949-1965. Deviations from the normal ATP content were measured with due to account of the natural variability of a given metabolite. For rats, deviations from the content of ATP in erythrocytes were short-term, those in neutrophils were long-term. For people, a statistically significant increase in the content of ATP in neutrophils as compared to the control was observed. A non-linear correlation between the content of ATP in neutrophils and the calculated dose of radiation was observed. An increase in the ATP content in whole blood, with regard to the control, was not statistically significant for all groups of examined persons.
生物发光法被用于研究电离辐射和/或异生物质对大鼠红细胞和中性粒细胞中ATP含量的影响，以及对1949 - 1965年在塞米巴拉金斯克一系列核试验期间遭受电离辐射的阿尔泰地区80名受检女性的全血和中性粒细胞中ATP含量的影响。考虑到给定代谢物的自然变异性，测量了与正常ATP含量的偏差。对于大鼠，红细胞中ATP含量的偏差是短期的，中性粒细胞中的偏差是长期的。对于人类，观察到与对照组相比，中性粒细胞中ATP含量有统计学显著增加。观察到中性粒细胞中ATP含量与计算出的辐射剂量之间存在非线性相关性。对于所有受检人群组，与对照组相比，全血中ATP含量的增加没有统计学显著性。
