Vasin M V, Antipov V V, Chernov G A, Abramov M M, Gavriliuk D N, L'vova T S, Suvorov N N
Radiats Biol Radioecol. 1997 Jan-Feb;37(1):46-55.
In the experiments on dogs, the role of a pharmacological circulatory hypoxia in the mechanism of radioprotective effect of indraline and mexamine was studied. Angiography revealed 20-40% vasoconstriction of major arteries of legs of animals, of pelvis and abdomen caused by mexamine (10 mg/kg) and the absence of a significant effect of indraline. Disruption of a regional blood circulation in the marrow and spleen (40-50% and 70-80%, respectively) was caused by indraline to the same extent as by mexamine. For indraline, a decrease in pO2 in the marrow was about 50%. With these hemodynamic disturbances, indraline showed 80 to 100% radioprotective effect, while mexamine was inefficient. Acute hypoxic hypoxia (5-7% O2) increased a post-radiation survival rate for dogs by 40%. The radioprotective effect of indraline was blocked by tropaphen and reduced in cases of breathing with pure oxygen. Splenectomy has no effect on radioprotective properties of indraline. Thus, a hypothesis of the mechanism of a radioprotective effect of alpha-adrenomimetics was proposed.
在对狗的实验中，研究了药理学循环性缺氧在因得列林和美金刚胺的辐射防护作用机制中的作用。血管造影显示，美金刚胺（10毫克/千克）可使动物腿部、骨盆和腹部的主要动脉血管收缩20%至40%，而因得列林无显著作用。因得列林对骨髓和脾脏局部血液循环的破坏程度（分别为40%至50%和70%至80%）与美金刚胺相同。因得列林使骨髓中的pO2降低约50%。在这些血流动力学紊乱情况下，因得列林显示出80%至100%的辐射防护作用，而美金刚胺则无效。急性低氧性缺氧（5%至7%氧气）可使狗的辐射后存活率提高40%。因得列林的辐射防护作用被托派芬阻断，在纯氧呼吸情况下作用减弱。脾切除术对因得列林的辐射防护特性无影响。因此，提出了关于α-肾上腺素能激动剂辐射防护作用机制的假说。
