Gekiere F, Dessalles M C, Poisson N, Maitre L
Centre hospitalier Paul Guiraud, Villejuif.
Encephale. 1996 Dec;22 Spec No 6:16-23.
The effects of clozapine were studied during 5 years at the Villejuif psychiatric hospital in outside and inside patients. Among the results obtained in 114 cases treated, we report here the results obtained in a group of 18 patients in which the longitudinal therapeutic data given by EEG recordings were confronted with those obtained for the plasma levels of the drug and it demethyl metabolite. This study shows on one side that EEG abnormal activities are frequent and need to be taken in account. On another hand we found an important inter as well as intra-variability of the plasma concentrations. For the intra-individual variations a large number of responsible factors was found. The interest to perform the demethyl metabolite dosage is discussed.
在维勒瑞夫精神病院，对住院和门诊患者进行了为期5年的氯氮平疗效研究。在114例接受治疗的患者所获得的结果中，我们在此报告一组18例患者的结果，其中脑电图记录给出的纵向治疗数据与该药物及其去甲基代谢物的血浆水平所获得的数据相对照。这项研究一方面表明脑电图异常活动很常见，需要予以考虑。另一方面，我们发现血浆浓度存在重要的个体间和个体内变异性。发现了大量导致个体内变异的因素。文中还讨论了进行去甲基代谢物剂量测定的意义。
