[炎症过程中氯氮平的毒性血浆浓度]

[Toxic plasma concentration of clozapine in inflammatory processes].

作者信息

van Gool A R, de Jong M H, Verhoeven W M A

机构信息

Yulius Geestelijke Gezondheid te Dordrecht en verbonden aan de afdeling Psychiatrie van het Erasmus MC te Rotterdam.

出版信息

Tijdschr Psychiatr. 2010;52(11):791-6.

PMID:21064022

Abstract

Clozapine has a narrow therapeutic range. The threshold value for plasma concentrations is 350 μg/l. If plasma concentrations exceed that value, serious side-effects can occur. An increase in plasma concentrations can occur as a result of inflammatory processes which may or may not be caused by an infection. Two cases are discussed in which the plasma concentration of clozapine increased as a result of an inflammatory reaction and signs of intoxication were observed. These developments seemed to be due to cholecystitis and bacterial pneumonia respectively. The clinical presentation and pathophysiology are discussed in relation to inflammatory processes.

摘要

氯氮平的治疗窗较窄。血浆浓度的阈值为350μg/l。如果血浆浓度超过该值，可能会出现严重的副作用。炎症过程可能导致血浆浓度升高，炎症可能由感染引起，也可能并非由感染引起。本文讨论了两例因炎症反应导致氯氮平血浆浓度升高并出现中毒迹象的病例。这些情况似乎分别是由胆囊炎和细菌性肺炎引起的。本文结合炎症过程对临床表现和病理生理学进行了讨论。