Adarichev V A, Korokhov N P, Ostapchuk Ia V, Dymshits G M, Markel' A L
Genetika. 1996 Dec;32(12):1669-72.
The properties of normotensive and hypertensive rat lines were investigated by the DNA fingerprinting method using a multilocus micro-satellite (CAC)5 probe. The HaeIII and HinfI restriction endonucleases were found to be the most informative enzymes in this case. The high genetic homogeneity of the ISIAH line, a rat line with inherited stress-sensitive arterial hypertension created at the Institute of Cytology and Genetics, was demonstrated. The lack of intralinear polymorphism was also typical to Japanese SHR rats with spontaneous arterial hypertension. Normotensive WAG rats had identical fingerprinting patterns, while the relative intensity of some bands was different. The outbred normotensive Wistar line maintained at the Institute, appeared to carry 30% polymorphic alleles. Hypertensive lines differed from the normotensive by a number of genetic markers.
利用多位点微卫星（CAC）5探针，通过DNA指纹图谱法研究了正常血压和高血压大鼠品系的特性。发现HaeIII和HinfI限制性内切酶在这种情况下是最具信息性的酶。细胞学与遗传学研究所培育的具有遗传性应激敏感性动脉高血压的ISIAH品系具有高度的遗传同质性。自发性动脉高血压的日本SHR大鼠也缺乏线粒体内多态性。正常血压的WAG大鼠具有相同的指纹图谱模式，而某些条带的相对强度有所不同。该研究所饲养的远交正常血压Wistar品系似乎携带30%的多态性等位基因。高血压品系在许多遗传标记上与正常血压品系不同。
