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[遗传性动脉高血压大鼠的行为特征]

[Features of the behavior of the rat with hereditarily determined arterial hypertension].

作者信息

Markel' A L

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1986 Sep-Oct;36(5):956-62.

PMID:3799074
Abstract

The behaviour of spontaneously hypertensive rats (SHR strain), rats with inherited stress induced arterial hypertension (ISIAH, a new developed strain), and of their normotensive Wistar progenitors was studied. The open-field arena and a device for measuring the total activity in the home cage were used in the behavioural studies. The SHR were much more active in the open--field and home cage tests than the Wistar and ISIAH rats. The basal locomotor activity of the ISIAH strain was lower than that of the Wistar rats, but the ISIAH strain had an index of behavioural reactivity 2.7 fold higher than the Wistar or SHR strains. These behavioural characteristics corresponded to the hypertension patterns of the strains compared. Enhanced spontaneous locomotion of the SHR rats was associated with spontaneous increase in arterial blood pressure. The ISIAH rats showed low spontaneous locomotor activity, but high behavioural and blood pressure reactivity under conditions of mild emotional stress.

摘要

研究了自发性高血压大鼠(SHR品系)、遗传性应激诱导动脉高血压大鼠(ISIAH,一种新培育的品系)及其血压正常的Wistar祖代大鼠的行为。行为学研究采用旷场试验场地和一种用于测量笼内总活动量的装置。在旷场试验和笼内试验中,SHR大鼠比Wistar大鼠和ISIAH大鼠活跃得多。ISIAH品系的基础运动活性低于Wistar大鼠,但ISIAH品系的行为反应指数比Wistar品系或SHR品系高2.7倍。这些行为特征与所比较品系的高血压模式相对应。SHR大鼠增强的自发运动与动脉血压的自发升高有关。ISIAH大鼠自发运动活性较低,但在轻度情绪应激条件下行为和血压反应性较高。

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