Cioni G, Ferrari A, D'Alimonte P, Turrini F, Tincani E, Cristani A, Rebecchi A M, Bagni A, Di Marco G, Ventura E
Cattedra e Divisione di Medicina Interna II, Università, Modena.
Recenti Prog Med. 1996 Dec;87(12):586-8.
211 patients were submitted to percutaneous ultrasound-guided liver biopsy: 184 patients (87.2%) had only one focal lesion, the other 27 had two or more lesions. In 9 patients (4.27%) the material drawn out from the liver was not adequate for microscopic examination (Retrieval Rate 95.7%). Histological evaluation revealed: absence of neoplasm in 67 patients (31.75%), benign lesion in 29 patients (13.74%), primitive malignant lesion in 70 patients (33.18%) and metastatic malignant lesion in 36 patients (17.06%). Combining the histological data with disease manifestation, biopsy showed a sensitivity of 95.1%, specificity of 100%, positive predictive value of 100%, negative predictive value of 89.4% and a diagnostic accuracy of 92.4%. None of the most important complications described in literature was observed. Our study confirms that ultrasound guided biopsy is a procedure of high diagnostic value in patients with nodular liver lesions, advantageous for its simplicity, low cost and safety.
211例患者接受了经皮超声引导下肝活检：184例患者（87.2%）仅有一个局灶性病变，另外27例有两个或更多病变。9例患者（4.27%）肝穿刺取材不适合显微镜检查（取材成功率95.7%）。组织学评估显示：67例患者（31.75%）无肿瘤，29例患者（13.74%）为良性病变，70例患者（33.18%）为原发性恶性病变，36例患者（17.06%）为转移性恶性病变。将组织学数据与疾病表现相结合，活检显示敏感性为95.1%，特异性为100%，阳性预测值为100%，阴性预测值为89.4%，诊断准确性为92.4%。未观察到文献中描述的任何重要并发症。我们的研究证实，超声引导下活检对肝脏结节性病变患者具有很高的诊断价值，因其操作简单、成本低且安全而具有优势。
