Djurić D, Rasić N, Popović Z, Vuković M, Bojić M
Institute of Physiology, University Medical School, Belgrade.
Srp Arh Celok Lek. 1996 May-Jun;124(5-6):139-42.
With findings of prostacyclin, known as a very potent antiplatelet, anticoagulant, vasodilator, a profibrinolytic and cytoprotective substance from arachidonic acid cascade, many different endothelium-derived vasoactive substances were discovered. It is known (1980) that intact endothelium is necessary for the vasorelaxant effect of acetylcholine in isolated rabbit aorta. The balance between relaxing and contracting factors of endothelial origin is very important for optimal blood vessel diameter and tissue perfusion. The existence of endothelium-derived vascular smooth muscle cells growth and proliferation factors is a new important dimension in the understanding of function of vascular endothelium.
随着前列腺素（一种来自花生四烯酸级联反应的强效抗血小板、抗凝、血管舒张、促纤溶和细胞保护物质）的发现，人们发现了许多不同的内皮源性血管活性物质。众所周知（1980年），完整的内皮对于乙酰胆碱在离体兔主动脉中的血管舒张作用是必需的。内皮源性舒张和收缩因子之间的平衡对于最佳血管直径和组织灌注非常重要。内皮源性血管平滑肌细胞生长和增殖因子的存在是理解血管内皮功能的一个新的重要方面。
