[Disorders of phosphate, calcium and magnesium ion metabolism in chronic renal insufficiency].

In hundred patients with different stages of renal functional damage, including the controls of healthy persons we examined the disturbances of phosphate, calcium and magnesium ion metabolism during chronic renal failure (CRF) progression. We also determined the serum levels of regulatory substances, parathormone and 1.25 dihydroxyvitamin D3 in 43 pts. grouped according to their group, sex, age average and season (autumn-winter) distribution. We established actual renal compensatory mechanisms for all of substances we determined, which were involved in homeostasis preservation of those substances. Some characteristic changes in plasma substance concentration and renal mechanisms of their regulation during CRF progression, suggest the following conclusions. No substances have preserved body homeostasis, although renal compensatory mechanism were expressed by different size for any of them. Those disturbances very tightly correlate with the stage of renal functional deterioration, as well as the serum parathormone rising and serum 1.25 DHHC decreasing.