Dimitrijević J, Maksić Dj, Spasić P, Hrvacević R
Institute of Pathology and Forensic Medicinae Militari Medical Academy, Belgrade.
Srp Arh Celok Lek. 1996;124 Suppl 1:29-32.
Some of tubulointerstitial changes are frequently found in glomerular disorders. A wide range of interstitial lesions have also been observed in patients with IgA nephropathy. Percutaneous biopsy specimens taken from 74 kidneys of IgA nephropathy patients have been analysed. Obtained tissues were examined by LM, If and EM. Light microscopy, immunofluorescence and electron microscopy Morphologic changes have been classified into 5 groups according to WHO classification. Interstitial changes, cellular infiltrations, fibrosis and other lesions from all renal tissues have been analysed and according to their intensity semiquantitatively graded into 4 groups. Histopathologic analysis has most frequently revealed interstitial fibrosis and less frequently mononuclear cellular infiltration particularly in patients with more prominent glomerular changes. Therefore, we have as well as other authors, confirmed that interstitial changes represent an important prognostic factor in the IgA nephropathy development. However, analysis of repeated biopsy specimens to confirm this hypothesis is necessary.
一些肾小管间质改变在肾小球疾病中经常出现。在IgA肾病患者中也观察到了广泛的间质病变。对74例IgA肾病患者的肾脏进行了经皮活检标本分析。所获得的组织通过光镜、免疫荧光和电镜进行检查。光镜、免疫荧光和电子显微镜 形态学改变根据WHO分类分为5组。对所有肾组织的间质改变、细胞浸润、纤维化和其他病变进行了分析，并根据其强度半定量分为4组。组织病理学分析最常显示间质纤维化，较少显示单核细胞浸润，特别是在肾小球改变更明显的患者中。因此，我们和其他作者一样，证实间质改变是IgA肾病发展的一个重要预后因素。然而，有必要分析重复活检标本以证实这一假设。
