Nagy J, Brasch H, Deák G, Sámik J, Süle T, Trinn C, Burger T
Acta Morphol Hung. 1984;32(2):143-54.
Renal biopsy material of 50 patients suffering from IgA glomerulonephritis was studied by light microscopy, immunofluorescence and occasionally electron microscopy. Associated with a uniform immunohistological pattern mainly focal or diffuse mesangial proliferative glomerulonephritis was found. In addition to the glomerular changes the importance of frequent extraglomerular, mainly vascular and interstitial, alterations is stressed. In arterioles and arteries, deposition of a hyalinous substance was observed. Immunohistology revealed the presence of immunoglobulins and/or C3 in the vessels. In the interstitium fibrinogen/fibrin was often seen, accompanied by chronic inflammatory infiltration and fibrosis.
对50例IgA肾小球肾炎患者的肾活检材料进行了光镜、免疫荧光检查，偶尔也进行了电镜检查。发现主要为局灶性或弥漫性系膜增生性肾小球肾炎，伴有一致的免疫组织学模式。除肾小球改变外，还强调了肾外改变（主要是血管和间质改变）频繁出现的重要性。在小动脉和动脉中，观察到透明样物质沉积。免疫组织学显示血管中存在免疫球蛋白和/或C3。在间质中，经常可见纤维蛋白原/纤维蛋白，伴有慢性炎症浸润和纤维化。
