Peco-Antić A, Nastić-Mirić D, Popović-Rolović M, Adanja G, Parezanović V, Pariović V, Jovanović I, Kostić M, Jovanović O, Kruscić D
University Children's Hospital, Belgrade.
Srp Arh Celok Lek. 1996;124 Suppl 1:92-4.
We analysed the effect of hemodialysis (HD) on endothelin (ET) plasma level in children with terminal renal failure. Twenty-five patients (pts) and 27 healthy children as controls were included in the study. There was no difference in ET plasma levels in pts before HD (1.97 +/- 1.45) and controls (2.08 +/- 1.47), but ET increased in plasma of pts after HD (4.10 +/- 3.66). To estimate the relationship of volume depletion or depuration on ET plasma level changes in pts during HD, ET was measured at three time points of HD (before ultrafiltration-UF, after UF, and after HD without fluid removal) in 10 pts. ET level was not significantly changed after UF (1.93 +/- 2.25 vs 1.71 +/- 1.50; ns), but was significantly increased after depuration (4.46 +/- 3.56; p < 0.05). There was no correlation between ET and blood pressure in controls and pts in either period of testing, neither with plasma renin activity, left ventricular mass index, and body weight changes during HD.
我们分析了血液透析（HD）对终末期肾衰竭患儿血浆内皮素（ET）水平的影响。本研究纳入了25例患者（pts）和27例健康儿童作为对照。患者血液透析前血浆ET水平（1.97±1.45）与对照组（2.08±1.47）无差异，但血液透析后患者血浆ET升高（4.10±3.66）。为评估血液透析期间容量减少或净化对患者血浆ET水平变化的影响，对10例患者在血液透析的三个时间点（超滤前、超滤后以及无液体清除的血液透析后）测量了ET。超滤后ET水平无显著变化（1.93±2.25对1.71±1.50；无显著性差异），但净化后显著升高（4.46±3.56；p<0.05）。在测试的任何时期，对照组和患者的ET与血压之间均无相关性，与血浆肾素活性、左心室质量指数以及血液透析期间的体重变化也均无相关性。
