Rootwelt T
Barneklinikken, Rikshospitalet, Oslo.
Tidsskr Nor Laegeforen. 1997 Feb 20;117(5):664-7.
Glucose is the most important cerebral fuel. During severe hypoxia-ischemia anaerobic glycolysis may partly replace oxidative phosphorylation as a source of energy, and in this situation high glucose levels may improve energy production. Despite this, it has been shown convincingly that, in adult animals, a high glucose level before global, cerebral ischemia increases the damage. In newborn animals the results are species-dependent. The importance of postischemic glucose levels is more uncertain. Few clinical intervention studies have been carried out, but some tentative guidelines can nevertheless be suggested.
葡萄糖是大脑最重要的能量来源。在严重缺氧缺血期间，无氧糖酵解可能部分替代氧化磷酸化成为能量来源，在这种情况下，高血糖水平可能会提高能量产生。尽管如此，已有确凿证据表明，在成年动物中，全脑缺血前的高血糖水平会加重损伤。在新生动物中，结果因物种而异。缺血后血糖水平的重要性更不确定。虽然进行的临床干预研究很少，但仍可提出一些初步指导原则。
