Boczoń K
Katedra Biologii i Parazytologii Lekarskiej, Akademia Medyczna im. Karola Marcinkowskiego, Poznań.
Wiad Parazytol. 1996;42(4):373-9.
In the review the results of the recent investigations and new ideas about the mode of action of neurotoxic anthelmintics are presented and discussed. Investigations of this group of drugs are very difficult, because our knowledge about neural system in helminths is still insufficient. However, some new perspectives have appeared recently. They concern such future targets of the drugs as acetylcholine transferase in filariae, a binding-site for ivermectin in Ascaris sp. or neuropeptides in nervous or neuromuscular system in Ascaris sp. The application of recombinant DNA techniques for cloning of parasite receptors, ion channels and protein involved in signal-transduction can be expected to lead to rapid progress in this field.
本综述介绍并讨论了近期关于神经毒性驱虫药作用方式的研究结果和新观点。对这类药物的研究非常困难，因为我们对蠕虫神经系统的了解仍然不足。然而，最近出现了一些新的观点。它们涉及该类药物未来的作用靶点，如丝虫中的乙酰胆碱转移酶、蛔虫中的伊维菌素结合位点或蛔虫神经或神经肌肉系统中的神经肽。预计应用重组DNA技术克隆寄生虫受体、离子通道和参与信号转导的蛋白质将在该领域取得快速进展。
