Wei J, Shaw L M, Mercurio A M
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
J Leukoc Biol. 1997 Apr;61(4):397-407. doi: 10.1002/jlb.61.4.397.
The adhesive interactions of leukocytes with basement membrane components and other extracellular matrix (ECM) proteins are mediated largely by the integrin family of receptors. These interactions can be regulated by various effector molecules including chemokines, growth factors, and other cell surface proteins by a mechanism termed inside-out signaling of integrin function. On engagement by their ligands, integrins activate a wide range of signaling pathways that regulate a broad array of leukocyte functions such as chemotaxis, cytokine responsiveness, phagocytosis, and gene expression. This review highlights recent advances in the understanding of integrin signaling in leukocytes with an emphasis on our own work on the alpha6beta1 integrin, the major laminin receptor expressed by these cells.
白细胞与基底膜成分及其他细胞外基质（ECM）蛋白的黏附相互作用主要由整合素受体家族介导。这些相互作用可由多种效应分子调节，包括趋化因子、生长因子和其他细胞表面蛋白，其调节机制称为整合素功能的外向内信号传导。整合素与配体结合后，会激活一系列广泛的信号通路，这些信号通路可调节多种白细胞功能，如趋化作用、细胞因子反应性、吞噬作用和基因表达。本综述重点介绍了白细胞整合素信号传导研究的最新进展，尤其着重于我们自己对α6β1整合素的研究工作，α6β1整合素是这些细胞表达的主要层粘连蛋白受体。
