Hughes P E, Pfaff M
Dept of Vascular Biology, Scripps Research Institute, La Jolla, CA 92037, USA.
Trends Cell Biol. 1998 Sep;8(9):359-64. doi: 10.1016/s0962-8924(98)01339-7.
Integrin cell-adhesion receptors mediate interactions between cells and the extracellular matrix. Dynamic regulation of integrin adhesive function is termed 'activation' or 'inside-out' signalling. Activation is key to integrin function in processes as diverse as cell migration, the organization of the extracellular matrix and platelet aggregation. Consequently, there has been an intense effort to elucidate the molecular mechanism of integrin activation. This has resulted in the recent identification of novel cytoplasmic partners for integrins and the emerging characterization of the signal-transduction pathways that regulate integrin 'inside-out' signalling. Here, the authors review the recent developments that have provided us with an increased understanding of the basis of integrin activation.
整合素细胞黏附受体介导细胞与细胞外基质之间的相互作用。整合素黏附功能的动态调节被称为“激活”或“由内向外”信号传导。激活是整合素在细胞迁移、细胞外基质组织和血小板聚集等多种过程中发挥功能的关键。因此，人们一直在深入努力阐明整合素激活的分子机制。这导致最近发现了整合素新的胞质结合蛋白，并对调节整合素“由内向外”信号传导的信号转导途径有了新的认识。在此，作者回顾了最近的进展，这些进展使我们对整合素激活的基础有了更深入的理解。
