Stewart M, Thiel M, Hogg N
Leukocyte Adhesion Laboratory, Imperial Cancer Research Fund, London, UK.
Curr Opin Cell Biol. 1995 Oct;7(5):690-6. doi: 10.1016/0955-0674(95)80111-1.
Lymphocytes, monocytes and granulocytes, which are collectively known as 'leukocytes', circulate primarily within the vascular system and lymphoid tissue but are found in essentially all tissues of the body. This mobile lifestyle necessitates the constant making and breaking of adhesive contacts with targets in their immediate environment. The adhesion receptors termed integrins, which are expressed in abundance by leukocytes, are well suited to carry out the transient interactions in which these cells engage. Major advances in the leukocyte integrin field this year have been the realization of the extensive roles for alpha 4 integrins in leukocyte function, the solution of the crystal structure of an I domain and its identification as a major ligand-binding site, and the initial understanding of how divalent cations may function in an active integrin.
淋巴细胞、单核细胞和粒细胞统称为“白细胞”，主要在血管系统和淋巴组织中循环，但几乎存在于身体的所有组织中。这种流动的生活方式使得它们需要不断地与周围环境中的目标建立和破坏粘附接触。白细胞大量表达的粘附受体称为整合素，非常适合进行这些细胞参与的瞬时相互作用。今年白细胞整合素领域的主要进展包括认识到α4整合素在白细胞功能中的广泛作用、I结构域晶体结构的解析及其作为主要配体结合位点的鉴定，以及对二价阳离子在活性整合素中可能如何发挥作用的初步理解。
