van Faassen A, Ochsenkühn T, Houterman S, van der Ploeg E M, Bueno-de-Mesquita B H, Ocké M C, Bayerdörffer E, Janknegt R A
Department of Urology, University Hospital, Maastricht, The Netherlands.
Cancer Lett. 1997 Mar 19;114(1-2):293-4. doi: 10.1016/s0304-3835(97)04683-1.
Bile acids are considered as a risk factor for colorectal carcinogenesis. They were analysed in samples of faecal water and plasma of fasting heparine blood from 23 urolithiasis patients. Linear regression showed that the highest percentage of variance (52%) was explained by the model: plasma deoxycholic acid (micromol/l) = -3.11 + 0.96(+/-0.25*) 10log deoxycholic acid in faecal water (micromol/l) + 0.35(+/-0.15*) pH of faecal water -0.41(+/-0.19#) defacation frequency (number of stools/day); *P < 0.05, #P = 0.055. In future studies, analysing blood levels of unconjugated deoxycholic acid may substitute faecal measurements.
胆汁酸被认为是结直肠癌发生的一个风险因素。对23名尿石症患者的粪便水样本和空腹肝素化血液的血浆中的胆汁酸进行了分析。线性回归显示，该模型解释了最高百分比的方差（52%）：血浆脱氧胆酸（微摩尔/升）=-3.11 + 0.96（±0.25*）×粪便水中脱氧胆酸（微摩尔/升）的10倍对数 + 0.35（±0.15*）×粪便水的pH值 - 0.41（±0.19#）×排便频率（每天排便次数）；*P < 0.05，#P = 0.055。在未来的研究中，分析未结合脱氧胆酸的血液水平可能会替代粪便测量。
