Chisty M M, Quddus R, Islam B, Khan B R
Department of Pathology, Dhaka Medical College.
Bangladesh Med Res Counc Bull. 1996 Aug;22(2):81-5.
A total of 40 NZW rabbits were selected for this study to see the effect of onion extract on immune response following antigenic challenge. These animals were randomly divided into four groups, each composed of ten rabbits. Group I and II were challenged with typhoid H (TH) antigen and groups III and IV with sheep red blood cells (SRBC). Groups I and III were considered as control and II and IV as treated groups. The latter two groups were treated with onion extract orally. The immunosuppressive effect of onion extract was evaluated by estimating antibody levels by Widal test and hemolysin titer. It was found that mean antibody titers were significantly lower in the treated groups than in controls. The weights of thymus and lymph nodes were higher and of adrenal glands were lower in the control groups than in the treated groups. It appeared from the current study that onion extract has an inhibitory effect on immune response.
本研究共选取40只新西兰白兔，以观察洋葱提取物对抗抗原攻击后免疫反应的影响。这些动物被随机分为四组，每组10只兔子。第一组和第二组用伤寒H（TH）抗原攻击，第三组和第四组用绵羊红细胞（SRBC）攻击。第一组和第三组被视为对照组，第二组和第四组为治疗组。后两组口服洋葱提取物。通过维达试验和溶血素滴度估计抗体水平来评估洋葱提取物的免疫抑制作用。结果发现，治疗组的平均抗体滴度显著低于对照组。对照组的胸腺和淋巴结重量高于治疗组，而肾上腺重量低于治疗组。从目前的研究来看，洋葱提取物对免疫反应有抑制作用。
