Niznikiewicz M A, O'Donnell B F, Nestor P G, Smith L, Law S, Karapelou M, Shenton M E, McCarley R W
Department of Psychiatry, Harvard Medical School, Massachusetts, USA.
J Abnorm Psychol. 1997 Feb;106(1):85-94. doi: 10.1037//0021-843x.106.1.85.
Language disturbance in schizophrenia has been recently attributed to disturbed priming mechanisms. In the present study, event-related potentials (ERPs), were recorded to final words in sentences presented to 13 chronic patients with schizophrenia and 12 normal controls. Half of the final words fit a sentence context and another half did not. The N400 (the ERP sensitive to language) latency was prolonged, and its amplitude was more negative to both correct and incorrect sentence endings in the group with schizophrenia relative to the group of normal controls. The early ERP components, N100 and P200, were similar in both groups. These results suggest that language abnormalities in schizophrenia are related to a dysfunction in the language system and not to a general cognitive dysfunction, and may be related to poor use of context in patients with schizophrenia.
精神分裂症中的语言障碍最近被归因于启动机制紊乱。在本研究中，记录了13名慢性精神分裂症患者和12名正常对照者在听句子时对句末单词的事件相关电位（ERP）。一半的句末单词符合句子语境，另一半则不符合。与正常对照组相比，精神分裂症组中对语言敏感的ERP成分N400潜伏期延长，且对正确和错误的句子结尾其波幅都更负。两组的早期ERP成分N100和P200相似。这些结果表明，精神分裂症中的语言异常与语言系统功能障碍有关，而非一般认知功能障碍，并且可能与精神分裂症患者对语境的利用不足有关。
