Simenhoff M L, Ginn H E, Teschan P E
Trans Am Soc Artif Intern Organs. 1977;23:560-5. doi: 10.1097/00002480-197700230-00150.
Fifty-three samples in 26 patients were analyzed for aliphatic amines (DMA and TMA), and the levels correlated with 2 neurophysiological tests, choice reaction time (CRT), and electroencephalogram (EEG). A significant correlation was found between TMA and CRT and EEG (p less than 0.001 and 0.003, respectively) and between DMA and CRT (p less than 0.01). These amines reflect part of the spectrum of toxic compounds which accumulate in uremia. Dissociation of neurophysiological functions may be helpful in evaluating various classes of potentially toxic compounds found in renal failure, as exemplified by short-chain aliphatic amines.
对26例患者的53份样本进行了脂肪族胺（二甲胺和三甲胺）分析，其水平与两项神经生理学测试、选择反应时间（CRT）和脑电图（EEG）相关。发现三甲胺与CRT和EEG之间存在显著相关性（分别为p<0.001和0.003），二甲胺与CRT之间存在显著相关性（p<0.01）。这些胺反映了尿毒症中积累的部分有毒化合物谱。神经生理功能的解离可能有助于评估肾衰竭中发现的各类潜在有毒化合物，短链脂肪族胺就是例证。
