Shishido M, Nagao N, Miyamoto K
Department of Pulmonary Medicine, Nagareyama Hospital, Chiba, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Feb;35(2):240-4.
A 60-year-old man was admitted to the hospital with anterior chest discomfort and superior vena cava syndrome. A chest X-ray film revealed a right upper mediastinal mass. A needle biopsy was done. Anaplastic tumor cells was found after HE staining. No melanin was found and the origin of the tumor cells could not be determined. Radiation and chemotherapy caused the tumor to shrink markedly. Because the tumor had invaded the superior vena cava, only reduction surgery could be done. The patient died 6 months after admission. Amelanotic malignant melanoma was diagnosed after immunohistochemical study of the resected specimen. Mediastinal malignant melanoma has been reported very infrequently and to our knowledge this is the first report of mediastinal amelanotic malignant melanoma.
一名60岁男性因前胸不适及上腔静脉综合征入院。胸部X线片显示右上纵隔肿块。进行了针吸活检。苏木精-伊红（HE）染色后发现间变性肿瘤细胞。未发现黑色素，肿瘤细胞的起源无法确定。放疗和化疗使肿瘤明显缩小。由于肿瘤侵犯了上腔静脉，只能进行减瘤手术。患者入院6个月后死亡。对切除标本进行免疫组化研究后诊断为无色素性恶性黑色素瘤。纵隔恶性黑色素瘤的报道非常罕见，据我们所知，这是纵隔无色素性恶性黑色素瘤的首例报道。
