Ijichi S, Ijichi N, Osame M
Nagahama Municipal Clinic, Faculty of Medicine, Kagoshima University.
Nihon Rinsho. 1997 Apr;55(4):926-33.
Human T lymphotropic virus type I(HTLV-I) is associated with the nonfatal neurologic disease, HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Many clinical signs of involvement outside the central nervous system (CNS) have been described in some patients with HAM/TSP and have triggered the discovery of some HTLV-I-associated concepts in the infected individuals without signs of CNS involvement. Most of these HTLV-I-associated diseases exhibit common possible viroimmunologic characteristics that include a distributional bias of HTLV-I activation between the blood flow and the affected lesions and accumulated cellular immune responses in the lesions. This review summarizes the recent perspectives of the molecular pathogenesis of HAM/TSP and other HTLV-I-associated diseases. Furthermore, the feasible pathogenic involvement of cellular interactions between infected cells and responding immunocompetent cells in the affected tissues is emphasized (bystander auto-aggressiveness).
人类嗜T淋巴细胞病毒I型（HTLV-I）与非致命性神经疾病——HTLV-I相关脊髓病/热带痉挛性截瘫（HAM/TSP）有关。一些HAM/TSP患者出现了中枢神经系统（CNS）以外受累的许多临床体征，这引发了在无CNS受累体征的感染个体中发现一些HTLV-I相关概念。这些HTLV-I相关疾病大多表现出共同的可能的病毒免疫学特征，包括HTLV-I在血流和受累病变之间激活的分布偏向以及病变中累积的细胞免疫反应。本综述总结了HAM/TSP和其他HTLV-I相关疾病分子发病机制的最新观点。此外，强调了受影响组织中感染细胞与有反应的免疫活性细胞之间细胞相互作用的可行致病作用（旁观者自身攻击性）。
