Ijichi S, Osame M
Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University.
Intern Med. 1995 Aug;34(8):713-21. doi: 10.2169/internalmedicine.34.713.
Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a well-defined clinicopathological entity, and approximately 1,900 patients with HAM/TSP have been reported in the world. Improved polymerase chain reaction (PCR)-based in situ techniques have allowed a better appreciation of the cellular localization of the virus activation in infected patients, and there is accumulating evidence that HAM/TSP is characterized by a distributional bias of viral activation between the blood flow and central nervous system (CNS). This review summarizes the current status of our understanding of HAM/TSP, and emphasizes the possible pathogenic involvement of cellular interactions between infected cells and responding immunocompetent cells in the CNS of patients with HAM/TSP. In addition, the notable systemic manifestations with or without myelopathy in HTLV-I-infected individuals are described.
人类嗜T淋巴细胞病毒I型（HTLV-I）相关脊髓病/热带痉挛性截瘫（HAM/TSP）是一种明确的临床病理实体，全球已报道约1900例HAM/TSP患者。基于聚合酶链反应（PCR）的原位技术的改进，使人们能更好地了解病毒在感染患者体内激活的细胞定位，并且越来越多的证据表明，HAM/TSP的特征是病毒激活在血流和中枢神经系统（CNS）之间存在分布偏差。本综述总结了我们目前对HAM/TSP的认识现状，并强调了感染细胞与HAM/TSP患者中枢神经系统中具有反应能力的免疫细胞之间细胞相互作用可能的致病作用。此外，还描述了HTLV-I感染个体中有无脊髓病的显著全身表现。
